(DETAILS OF THE RESEARCH PROJECTS COMPLETED & ONGOING ) |
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Year |
Projects |
Investigator |
11/90 to 4/92 |
Echocardiographic study of valvular heart disease prevalence among school children in Jaipur |
Dr. Rajeev Gupta |
4/92 to 3/96 |
Epidemiological study of coronary heart disease and risk factor prevalence in rural and urban populations of Rajasthan, Jaipur Heart Watch Phase 1 Rs. 400000. |
Dr. Rajeev Gupta |
5/93 to 6/94 |
Cholesterol lowering effects of some plants found in Rajasthan |
Dr. Rajeev Gupta |
5/96 to 3/98 |
Anti-oxidant phenolics and flavonoids in common Indian foods and their importance in coronary heart disease patients. |
Dr. Rajeev Gupta |
8/97 to 9/01 |
Jaipur Heart Watch Phase 2 Study of trends in coronary heart disease and risk factors in urban subjects. |
Dr. Rajeev Gupta |
4/01 to date |
Jaipur Heart Watch Phase 3 Study of trends in coronary heart disease and risk factors in urban subjects. Bhatia Community Study |
Dr. Rajeev Gupta |
4/03 to date |
Thrombotic coronary risk factors in young CAD patients in Rajasthan Case Control Study |
Dr. Rajeev Gupta |
4/04 to date |
Jaipur Heart Watch Phase 4 Coronary risk factors in urban subjects Bhatia Community Study |
Dr. Rajeev Gupta |
4/99 to 2/03 |
OASIS 2 Study : Observational study of practice patterns in acute unstable coronary syndromes An international multicentric collaborative project |
Dr. Rajeev Gupta |
4/00 to date |
CREATE Registry of acute coronary syndrome practive patterns in India steering committee member. |
Dr. Rajeev Gupta |
12/01 to date |
CREATE Study : Clivarine in acute myocardial infaraction, steering committee member |
Dr. Rajeev Gupta |
6/02 to date |
PURE Study: Prospective Urban Rural Health Evaluation Study – India Steering Committee member. |
Dr. Rajeev Gupta |
10/03 to date |
POISE Study: Perioperative ischaemia study. |
Dr. Rajeev Gupta |
10/03 to date |
OASIS-6 Michelangelo Study: Comparison of enoxaparin and fondipareneux in acute coronary syndromes. A multicentric randomized trial |
Dr. Rajeev Gupta |
10/03 to date |
VITATOPS Study: Vitamins to prevent stroke. A multicentric international randomized trial |
Dr. Rajeev Gupta |
7/04 to date |
ProFESS Study: Comparison of clopidogrel aspirin and aspirin dipyradiomole in prevention of recurrent strokes. |
Dr. Rajaram Agarwal |
7/04 to date |
Genetic determinants of diabetic nephropathy. Collaborative research with Delhi University. |
Dr. A.K. Sharma |
4/03 to 10/03 |
Panacea Biotec Study: Lovastatin niacin combination in treatment of high cholesterol.( Post Marketing Surveillance) |
Dr. Rajeev Gupta |
9/03 to 12/03 |
Crestor Study: Astra Zeneca Randomised trial of rosuvastatin vs atorvastatin in treatment of high LDL cholesterol.( Post Marketing Surveillance) |
Dr. Rajeev Gupta |
5/03 to date |
Panacea Biotech Study. Evaluation of atorvastatin ezetimibe combination in moderate hypercholesterolemia. Randomized Controlled Trial |
Dr. Rajeev Gupta |
ONGOING EPIDEMIOLOGICAL RESEARCH PROJECTS |
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Study |
Focus |
Sponsor |
Current Status |
PURE (Prospective urban rural epidemiology study) |
15 years prospective study of risk factors and outcomes in cardiovascular diseases in urban and rural population in 15 locations in India and 15 countries worldwide (n=150,000). |
St John Medical College Bangalore; and Mc Master University, Hamilton, Canada. |
Target = 5000. |
DST-Women’s Health study |
Study of risk factors for chronic diseases in middle aged women and effect of educational interventions at 8 locations in India (n = 10,000) |
All India Institute of Medical Sciences, New Delhi; and Department of Science and Technology, Government of India. |
Target = 1000 |
India Heart Watch and Jaipur Heart Watch –5 |
Study of cardiovascular risk factors among adults in >20 Indian urban locations in every Indian state (n=10,000) |
Monilek Hospital and Research Centre, Jaipur and South Asian Society of atherosclerosis and Thrombosis, Bangalore and Minneapolis, USA. |
Recruitment =1775 |
WDF- MARG study |
Study of knowledge and awareness regarding obesity and diabetes among school children in 3 locations in India and effect of nutritional education intervention (n=25000) |
World Diabetes Federation, Copenhagen, Denmark; and Diabetes Foundation of India/ Fortis Hospital, New Delhi. |
Target = 10,000 |
SRS-VA study million Deaths study |
Prospective study of causes of deaths in India and effect of life style factors on cause of deaths (India –wide study) |
Sample registration survey and Registrar General of India, New Delhi; and university of Toronto, Toronto, Canada. |
Target = 1000 |
Inter Stroke |
Indian standardized case- control study to identify conventional and emerging risk factor associated with stroke. |
St Johns Research Institute, Bangalore. |
Target = 30 case and control each. |
DEPARTMENT OF RESEARCH ONGOING CLINICAL TRIALS |
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STUDY TITLE |
OBJECTIVE |
SPONSOR |
STATUS |
POISE STUDY |
PERIPOERATIVE ISCHEMIA STUDY IN HIGH RISK CARDIAC PATIENTS UNDERGOING NON-CARDIAC SURGERY |
ST. JOHN’S MEDICAL COLLEGE, BANGLORE AND MCMASTER UNIVERSITY OF CANADA |
TARGET=50 RECRUITMENT=64 |
PROFESS STUDY |
RANDOMISED STUDY OF CLOPIDOGREL VERSUS ASPIRIN-DIPYRAMIDOLE FOR PREVENTION OF SECOND STROKES |
ST JOHN’S MEDICAL COLLEGE BANGLORE UNIVERSITY OF MUNICH GERMANY AND MCMASTER UNIVERSITY CANADA |
RECRUITMENT=30 FOLLOW-UP ONGOING |
HAP STUDY |
PHASE-3 RANDOMISED TRIAL OF TELEVANCIN VERSUS VANCOMYCIN IN HOSPITAL ACQUIRED GRAM-POSITIVE PNEUMONIA |
QUINTILES INDIA LTD. MUMBAI |
COMPLETED SITE CLOSED OUT |
DPP-4 EARLY DIABETES STUDY |
PHASE-2 EVALUATION OF A NOVEL DPP-4 INHIBITOR IN NEWLY DIAGNOSED DIABETES |
SIRO CLINPHARM LTD. MUMBAI |
COMPLETED SITE CLOSED OUT |
SONOMA STUDY |
PHASE-3 STUDY OF A NOVEL ANTITHROMBOTIC DRUG IN TREATMENT OF VENOUS CATHETER THROMBOSIS |
QUINTILES INDIA LTD. MUMBAI |
COMPLETED SITE CLOSED OUT |
RED HEART PILL STUDY |
PROOF OF EFFICACY STUDY OF COMBINATION POLYPHARMACY IN CARDIOVASCULAR DISEASES |
DR. REDDY’S LAB HYDERABAD |
25 SUBJECTS RECRUITED VISITS COMPLETED OF ALL SUBJECTS |
RIO- INDIA STUDY |
PHASE-3 STUDY OF SAFETY AND EFFICACY OF RIM0NABANT IN HIGH-RISK OBESE SUBJECTS |
CIPLA INDIA LTD. MUMBAI |
10 SUBJECTS RECRUITED |
POLYCAP STUDY |
PHASE-4 RANDOMISED TRIAL OF SAFETY AND EFFICACY OF INDIVIDUAL COMPONENTS AND DIFFERENT COMBINATIONS OF POLYPILL IN INDIAN SCENARIO |
ST JOHN’S MEDICAL COLLEGE BANGLORE AND MCMASTER UNIVERSITY CANADA |
ONGOING |
VITATOPS STUDY |
HOMOCYSTEINE LOWERING VITAMINS TO |
ST. JOHN’S MEDICAL COLLEGE BANGLORE AND UNIVERSITY OF WESTERN AUSTRALIA PERTH AUSTRALIA |
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Denosumab study |
PHASE-3 DOUBLE BLIND PLACEBO CONTROLLED STUDY OF DENOSUMAB IN PROLONGING BONE METASTASISIN HORMONE REFRACTORY PROSTRATE CANCER |
AMGEN INC CA QUINTILES |
ONGOING |
STATUS OF CLINICAL TRIALS |
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Study Name / Code |
Indication |
Principal Investigator |
Status | Sponsor / CRO |
Polycap |
Cardio-vascular risk factor |
Dr. Rajeev Gupta |
Ongoing 31 Screened 20 Randomized |
CADILA PHARMA CEUT. LTD. |
MAP0010- |
Asthamtic infants and childer |
Dr. Ashok Kabra |
Ongoing 22 Screened 17 Randomized |
MAP PHARMA, INC. |
Vitatops |
Vitamins |
Dr. Rajeev Gupta |
Ongoing 30 Randomized |
St. John's Medical College |
CINACAET / MAC/2007 |
Secondary Hyperparat Hydrodism |
Dr. A.K. Sharma |
Ongoing 10 Screened 2 Randomized |
MACLEODS PHARMA LTD. |
E3810-G000-301 (GERD) |
GERD |
Dr. Mukesh Kumar Sarna |
Site Initiation Pending | EISAI |
E5555-G000-202 (ACS) |
Acute Coronary Syndrome |
Dr. Mukesh Kumar Sarna |
Site Initiation Done | EISAI |
P903-08 (CAP) |
Community - Acquired Pneumonia |
Dr. Mukesh Kumar Sarna |
Site Initiation Pending | Cerexa, Inc. ("Cerexa") |
2-001 (DIC Sepsis) |
DIC Sepsis |
Dr. Mukesh Kumar Sarna |
Site Initiation Pending | Artisan Pharma, Inc. |
MLN 002 |
Ulcerative Colites |
Dr. Mukesh Kumar Sarna |
EC Approval Pending | Boehringer Ingelheim |
EPO HEXAL (HX575) |
Anaemia |
Dr. A.K. Sharma |
EC Approval Pending | HEXAL Biotech Forschungs GmbH |